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	Important Safety Info. Clinical Pharmacology Mechanism Of Action Pharmacokinetics Profile Drug Interactions Adverse Events	Breast Cancer Taxotere® Benefits Lung Cancer Taxotere® Benefits Prostate Cancer Taxotere® Benefits Gastric Cancer Taxotere® Benefits Head & Neck Cancer Taxotere® Benefits	Dosing Guide Dosing Adjustment Taxotere® Preparation Handling of Taxotere®	Patient Education Useful Patient Web Sites	Useful Links Reimbursement PACT + Nurses' Section For Your Patients Nurses' Resources

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IMPORTANT SAFETY INFORMATION

WARNING
The incidence of treatment-related mortality associated with Taxotere® therapy is increased in patients with abnormal liver function, in patients receiving higher doses, and in patients with non-small cell lung carcinoma and a history of prior treatment with platinum-based chemotherapy who receive Taxotere® as a single agent at a dose of 100 mg/m² (see WARNINGS section of the prescribing information)

Continued below

Nurses' Resources

As a nurse, you play a very important role in your patients' Taxotere^® chemotherapy treatment. This section currently provides comprehensive Taxotere^® resources to help you and your breast, lung, prostate, gastric, cancer patients better understand Taxotere^® treatment, including:

An interactive Taxotere^® dosing guide - a quick reference on Taxotere^® dosing and administration, pre-medication, and dosing modifications to address adverse events in breast, lung and prostate cancer patients.

Taxotere^® pre-med sheets, currently offering your cancer patients easy instructions on taking their premedication.

Lung	English	Espanõl
Prostate	English	Espanõl
Gastric	English	Espanõl
Head and Neck	English	Espanõl

2009 Oncology Nursing Conferences

Palliative Medicine & Supportive Oncology Symposium 2009

March 5-7, 2009
Fort Lauderdale, Florida

The Assosication of Pediatric Hematology/Oncology Nurses' and the Children's Oncology Group's Nursing Workshop

March 10-11, 2009
Dallas, Texas

National Comprehensive Cancer Network 14th Annual Conference: Clinical Practice Guidelines & Quality Cancer Care

March 11-15, 2009
Hollywood, Florida

Oncology Nursing Symposium: Advancing the Possibilities

March 20-21, 2009
Stone Mountain, Georgia

Oncology Nursing Society Annual Congress

April 30-May 3, 2009
San Antonio, Texas

American Head & Neck Society

May 30-31, 2009
Phoenix, Arizona

Oncology Clinical Issues and Trends

September 14-16, 2009
Washington, DC

29th Annual Oncology Nurses Symp

October 4-7, 2009
San Diego, California

Oncology Learning Society 10th Annual Institutes of Learning

November 13-15, 2009
Tampa, Florida

Be sure to visit this section often for additional resources and updated information.

IMPORTANT SAFETY INFORMATION

WARNING:

The incidence of treatment-related mortality associated with Taxotere® therapy is increased in patients with abnormal liver function, in patients receiving higher doses, and in patients with non-small cell lung carcinoma and a history of prior treatment with platinum-based chemotherapy who receive Taxotere® as a single agent at a dose of 100 mg/m² (see WARNINGS and PRECAUTIONS section of the prescribing information)
Taxotere^® should generally not be given to patients with bilirubin > upper limit of normal (ULN), or to patients with serum glutamic-oxaloacetic transaminase (SGOT) and/or serum glutamic-pyruvic transaminase (SGPT) > 1.5 X ULN concomitant with alkaline phosphatase > 2.5 X ULN
- Patients with elevations of bilirubin or abnormalities of transaminase concurrent with alkaline phosphatase are at increased risk for the development of grade 4 neutropenia, febrile neutropenia, infections, severe thrombocytopenia, severe stomatitis, severe skin toxicity, and toxic death
- Patients with isolated elevations of transaminase > 1.5 X ULN also had a higher rate of febrile neutropenia grade 4 but did not have an increased incidence of toxic death
- Bilirubin, SGOT or SGPT, and alkaline phosphatase values should be obtained prior to each cycle of Taxotere^® therapy and reviewed by the treating physician
Taxotere^® therapy should not be given to patients with neutrophil counts of < 1500 cells/mm³
- In order to monitor the occurrence of neutropenia, which may be severe and result in infection, frequent blood-cell counts should be performed on all patients receiving Taxotere^®
Severe hypersensitivity reactions characterized by generalized rash/erythema, hypotension and/or bronchospasm, or very rarely fatal anaphylaxis, have been reported in patients who received the recommended 3-day dexamethasone premedication
- Hypersensitivity reactions require immediate discontinuation of Taxotere^® infusion and administration of appropriate therapy (see WARNINGS AND PRECAUTIONS section of the prescribing information)
Taxotere^® must not be given to patients who have a history of severe hypersensitivity reactions to Taxotere^® or to other drugs formulated with polysorbate 80 (see CONTRAINDICATIONS section of the prescribing information)
Severe fluid retention occurred in 6.5% (6/92) of patients despite use of a 3-day dexamethasone premedication regimen. It was characterized by one or more of the following events: poorly tolerated peripheral edema, generalized edema, pleural effusion requiring urgent drainage, dyspnea at rest, cardiac tamponade, or pronounced abdominal distention (due to ascites) (see WARNINGS and PRECAUTIONS section of the prescribing information)

Additional Warnings

All patients should be premedicated with oral corticosteroids such as dexamethasone (see DOSAGE AND ADMINISTRATION section of the prescribing information)
Neutropenia (<2,000 neutrophils/mm³) occurs in virtually all patients given 60-100 mg/m² of Taxotere^® and grade 4 neutropenia (<500 cells/mm³) occurs in 85% of patients given 100 mg/m² and 75% of patients given 60 mg/m²
Treatment-related acute myeloid leukemia (AML) or myelodysplasia has occurred in patients given anthracyclines and/or cyclophosphamide, including use with Taxotere^® in adjuvant therapy of breast cancer
Taxotere^® can cause fetal harm when administered to pregnant women. Women of childbearing potential should be advised to avoid becoming pregnant during therapy with Taxotere^®
Patients with pre-existing effusions should be closely monitored from the first dose for possible exacerbation of the effusions.

Precautions

Localized erythema of the extremities with edema followed by desquamation has been observed
- In case of severe skin toxicity, an adjustment in dosage is recommended (see DOSAGE AND ADMINISTRATION section of the prescribing information)
Severe neurosensory symptoms (paresthesia, dysesthesia, pain) were observed in 5.5% (53/965) of metastatic breast cancer patients, and resulted in treatment discontinuation in 6.1%
- When these symptoms occur, dosage must be adjusted; if symptoms persist, treatment should be discontinued (see DOSAGE AND ADMINISTRATION section of the prescribing information)
Severe asthenia was reported in 14.9% (144/965) of metastatic breast cancer patients, but led to treatment discontinuation in only 1.8%
- Symptoms of fatigue and weakness may last a few days up to several weeks and may be associated with deterioration of performance status in patients with progressive disease
In patients treated with TCF for gastric cancer, the incidence of serious adverse events was higher in patients >65 years than in younger patients. Adverse events (all grades) occurring at rates >10% higher in elderly patients included lethargy, stomatitis, diarrhea, dizziness, edema, and febrile neutropenia/neutropenic infection.
Taxotere^® should be administered only under the supervision of a qualified physician experienced in the use of antineoplastic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available

Please see accompanying full prescribing information, including boxed WARNING.

Taxotere Indications

Breast Cancer
TAXOTERE^® is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy
TAXOTERE^® in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer

Non-Small Cell Lung Cancer
TAXOTERE^®, as a single agent, is indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure of prior platinum-based chemotherapy
TAXOTERE^® in combination with cisplatin is indicated for the treatment of patients with unresectable, locally advanced or metastatic NSCLC who have not previously received chemotherapy for this condition.

Prostate Cancer
TAXOTERE^® in combination with prednisone is indicated for the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer.

Gastric Cancer
TAXOTERE^® in combination with cisplatin and fluorouracil is indicated for the treatment of patients with advanced gastric adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for advanced disease.

Head and Neck Cancer
TAXOTERE^® in combination with cisplatin and fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN).